Development of protease inhibitors for protozoan infections
نویسندگان
چکیده
منابع مشابه
HIV Protease Inhibitors: Effect on the Opportunistic Protozoan Parasites
The impact of highly active antiretroviral therapy (HAART) in the natural history of AIDS disease has been allowed to prolong the survival of people with HIV infection, particularly whose with increased HIV viral load. Additionally, the antiretroviral therapy could exert a certain degree of protection against parasitic diseases. A number of studies have been evidenced a decrease in the incidenc...
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Background and Aim: Advent of COVID-19 attracted the attentions of researchers to develop drugs for its treatment. Besides efforts on developing new drugs, screening available drugs for efficacy on COVID-19 could be an urgent action of initiating its pharmacotherapy. In this study, efficacy of HIV protease inhibitors on COVID-19 protease has been examined. Methods: Molecular docking based scree...
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Leishmaniasis is a deadly protozoan parasitic disease affecting millions of people worldwide. The treatment strategy of Leishmania infection depends exclusively on chemotherapy till date. But the treatment of the disease is greatly hampered due to high cost, toxicity of the available drugs and more importantly emergence of drug resistance. Hence the potential new drugs are highly needed to comb...
متن کاملImmunology and Molecular Biology of Protozoan Infections
The protozoan parasites, which cause important diseases affecting million of people worldwide especially in the tropical and subtropical areas, are responsible for high mortality and morbidity. Most of these parasites are transmitted by insect vectors and invade a range of different tissues in their mammalian hosts. Prophylactic and therapeutic strategies are far from satisfactory. Indeed, alth...
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Aspartic proteases are relatively a small group of proteolytic enzymes. Over the last decade, they have received tremendous research interest as potential targets for pharmaceutical intervention as many have been shown to play significant roles in physiological and pathological processes. Despite numerous efforts, however, the only inhibitors for aspartic proteases currently in the market are d...
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ژورنال
عنوان ژورنال: Current Opinion in Infectious Diseases
سال: 2008
ISSN: 0951-7375
DOI: 10.1097/qco.0b013e328315cca9